REGENTO™
Bone Void Filler

Particulate graft with engineered macroporosity to promote protein deposition and cell attachment.

Product Overview

REGENTO is comprised of resorbable, particulate b-TCP granules and supplied in a sterile, single use kit. REGENTO granules are provided “ready-to-use”, however the granules may be combined with sterile physiological solution, autologous bone marrow aspirate or blood prior to implantation. REGENTO granules are resorbed and remodeled by the body as new bone formation occurs during the healing process.

REGENTO is intended for use to fill bony voids or defects of the skeletal system (i.e. posterolateral spine, extremities and pelvis) that may be surgically created or osseous defects created from traumatic injury to the bone.

Importance of porosity

Interconnected macro and microporosity have been shown to positively influence the bioactivity and performance of bone grafting materials. As pictured below, REGENTO particles are characterized by a network of microporous channels and surface “pitting”, which maximizes overall surface area, leading to enhanced protein deposition and cell attachment. The network of porosity further enables remodeling to incur from within, as well as outside, each granule.

Scanning electron microscopy (SEM) image at 30X magnification

Hing et al. Journal of Materials Science: Materials in Medicine (2005); Hannink et al. Injury (2011); Bignon et al. Journal of Materials Science: Materials in Medicine (2003).

 

Additional Performance Characteristics

Composition b-TCP (tricalcium phosphate)
Osteoconductive Slowly remodels and is progressively replaced with native bone during the repair process
Porosity 80%, multi-directional, interconnected
Macroporosity Up to 300µm
Flexibility Can be combined with autologous blood or bone marrow aspirate
Storage Room temperature
Particle Sizes 1,000-2,000µm; 2,000-3,350µm
Kit Sizes 1cc, 5cc, 10cc, 20cc, 30cc (1,000-2,000µm)
5cc, 10cc, 20cc, 30cc (2,000-3,350µm)